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输入用最敏感的检测方法测定HBsAg为阴性者的血液,偶而也可发生乙型肝炎。在某些情况下,供血者很可能是隐性的“低水平”乙型肝炎病毒感染者。虽然测不出HBsAg的含量,但具有高滴度的乙型肝炎核心抗体(抗-HBc)。它们的存在,以前尚未得到血清学及流行病学研究的证实。本文作者报道了一名这样的供血者,此供血者引起了2例具有临床症状的输血后乙型肝炎,1例于1976年发病,另1例于1981年发病。在这期间,还有一名受血者,在输血前抗-HBs与抗-HBc皆为阳性,但在输血后7天其抗-HBs浓度则有10~4倍以上增高
Enter the most sensitive detection method for the determination of HBsAg-negative blood, and occasionally can occur in Hepatitis B. In some cases, donors are most likely to be recessive “low” hepatitis B virus infections. Although HBsAg is undetectable, it has a high titer of hepatitis B core antibody (anti-HBc). Their existence has not previously been confirmed by serological and epidemiological studies. The authors of the paper reported one such donor who caused two post-transfusion hepatitis B attacks with clinical symptoms, one in 1976 and the other in 1981. During this period, there was also a blood recipient who was positive for both anti-HBs and anti-HBc before transfusion, but had an anti-HBs concentration 10 to 4-fold increase over 7 days after blood transfusion