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[目的]观察强化细则罗马Ⅲ标准的一般疗法辅助普芦卡必利治疗老年功能性便秘的临床综合疗效。[方法]选择老年功能性便秘134例,按照序数分为观察组、对照组,各67例,观察组给予强化细则罗马Ⅲ标准的一般疗法辅助普芦卡必利,对照组给予一般疗法辅助普芦卡必利,观察2组患者治疗前、治疗3个月后的症状积分变化,指标包括:排便困难、过度用力排便;粪便性状;排便时间;不尽、坠胀感;频率;腹胀;总积分等量化项目,问卷调查2组治疗前后SF-36健康量表变化。[结果]观察组与对照组治疗后便秘各症状积分以及生理功能、总体健康、活力、情感职能等9个维度的生活质量评分均较治疗前有明显改善。治疗后观察组的总有效率95.52%(64/67)明显高于对照组的53.73%(36/67),P<0.01;观察组、对照组在治疗后便秘总积分平均疗效指数分别为64.13%、33.03%,2组比较差异有统计学意义(P<0.05);治疗后观察组粪便性状、每次排便时间及每周排便次数积分改善幅度均好于对照组,生理功能、情感职能2个维度评分明显高于对照组(均P<0.01)。[结论]强化细则的罗马Ⅲ标准的一般疗法辅助普芦卡必利治疗老年功能性便秘,具有良好的疗效,易被老年患者接受,能显著改善功能性便秘的临床症状及其生命质量。
[Objective] To observe the clinical efficacy of generalized therapy of Rome III standard assisted by propafarapride in elderly patients with functional constipation. [Methods] A total of 134 elderly patients with functional constipation were selected and divided into observation group, control group and 67 patients in each group according to the ordinal number. The observation group was given the general rule of Rome Ⅲ standard propranolol and the control group was given general therapy Carbaryl, observed two groups of patients before treatment, after treatment for 3 months the symptom score changes, indicators include: defecation, over forced defecation; stool characteristics; defecation time; endless, dilatory; frequency; abdominal distension; total Points and other quantitative items, questionnaire survey before and after treatment SF-36 health scale changes. [Results] The scores of constipation symptom scores and the quality of life scores of 9 dimensions including physical function, general health, vitality and emotional function of the observation group and the control group were significantly improved after treatment. After treatment, the total effective rate of the observation group was 95.52% (64/67), which was significantly higher than that of the control group (53.73%, 36/67), P <0.01. The average effective index of the constipation total score of the observation group and the control group after treatment was 64.13 %, 33.03% respectively. There was significant difference between the two groups (P <0.05). After treatment, the improvement of stool performance, defecation time and weekly defecation frequency in the observation group were better than those in the control group. Physiological function and emotional function 2 The dimension of each dimension was significantly higher than that of the control group (all P <0.01). [Conclusion] The general therapy of Rome Ⅲ standard that reinforces the rules and regulations is helpful to the treatment of senile functional constipation with prophylactly. It has good curative effect and is easy to be accepted by elderly patients. It can significantly improve the clinical symptoms and quality of life of functional constipation.