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目的:了解青岛港中老年人群血浆总同型半胱氨酸在不同性别、年龄组的分布特点,分析血浆总同型半胱氨酸与相关危险因素的关系。方法:于2000-03以山东青岛港年龄40岁以上中老年职工3940名为研究对象。根据心脑血管疾病危险因素进行问卷调查:①调查表:一般情况(被调查者的年龄、性别、职业及婚姻等情况)、既往病史(冠心病史、脑卒中史等)、个人史(如吸烟史、饮酒史)及家族史等。②体格检查:包括身高、体质量、血压的测量,心肺查体。③心电图检查。④血液学检查(包括血糖、血脂分析、血浆总同型半胱氨酸、血肌酐等)。高血浆总同型半胱氨酸血症诊断标准:按照整个体检人群75%的总同型半胱氨酸水平作为分组标准,即17μmol/L为分界点。高于此分界点为高总同型半胱氨酸血症。对总同型半胱氨酸的分布特点及传统心脑血管疾病危险因素进行统计学分析。结果:调查纳入3940名,男2937名,女1003名;平均年龄(53±9)岁。3940名入选者血浆总同型半胱氨酸分布范围为2.53～115.77μmol/L。①血浆总同型半胱氨酸的几何均数:男性为14.98μmol/L,女性为11.33μmol/L,男性高于女性(P<0.001)。②各年龄组男性总同型半胱氨酸水平均高于女性(各组P<0.05);年龄>60岁组血浆同型半胱氨酸水平男、女均高于年龄<60岁组(P<0.05)。③Logistic回归分析:男性、年龄、收缩压、体质量指数、肌酐清除率和心脑血管疾病史是血浆总同型半胱氨酸升高的危险因素。结论:①青岛港中老年人群血浆总同型半胱氨酸水平存在年龄、性别差异。②血浆总同型半胱氨酸的主要危险因素包括男性、年龄、收缩压、体质量指数、肌酐清除率和心脑血管疾病史。
Objective: To understand the distribution characteristics of total plasma homocysteine in different age groups in middle-aged and elderly people in Qingdao Port, and to analyze the relationship between total plasma homocysteine and related risk factors. METHODS: A total of 3940 elderly and middle-aged employees over 40 years old in Qingdao Port, Shandong Province, were selected as study subjects from 2000-03. According to risk factors of cardiovascular and cerebrovascular diseases, a questionnaire survey was conducted: 1 Questionnaire: general conditions (age, sex, occupation, marriage, etc.), past medical history (history of coronary heart disease, history of stroke, etc.), personal history (such as History of smoking, drinking history, and family history. 2 physical examination: including height, body weight, blood pressure measurement, cardiopulmonary examination. 3 ECG examination. 4 Hematological examination (including blood glucose, lipid analysis, plasma homocysteine, serum creatinine, etc.). High plasma total homocysteine diagnostic criteria: According to the total physical examination population 75% of the total homocysteine level as a group standard, that is 17μmol/L cut-off point. Above this cut-off point is high total homocysteinemia. The distribution of total homocysteine and the risk factors of traditional cardiovascular and cerebrovascular diseases were statistically analyzed. Results: The survey included 3,940 males, 2,937 males and 1,003 females; the average age was (53±9) years. The total plasma homocysteine distribution ranged from 2.53 to 115.77 μmol/L in 3940 candidates. 1 The geometric mean of total homocysteine in plasma was 14.98 μmol/L in males and 11.33 μmol/L in females, which was higher in males than in females (P<0.001). 2The mean level of homocysteine was higher in males than in females in each age group (P<0.05 in each group); the plasma homocysteine level was higher in males and females in the age group >60 years than in those aged <60 years (P< 0.05). 3Logistic regression analysis: Male, age, systolic blood pressure, body mass index, creatinine clearance and history of cardiovascular and cerebrovascular diseases were risk factors for plasma total homocysteine elevation. Conclusions: 1 The plasma homocysteine levels in middle-aged and elderly people in Qingdao harbor have differences in age and gender. 2 The main risk factors for total plasma homocysteine include male, age, systolic blood pressure, body mass index, creatinine clearance, and history of cardiovascular and cerebrovascular diseases.