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目的分析染色体异染色质区增加与生殖相关的临床效应。方法对6958例生殖异常患者通过取外周血淋巴细胞培养,显带进行染色体核型分析。结果检出染色体异染色质区增加196例,占被检患者的2.82%。结论染色体异染色质区增加导致自然流产、不孕不育、死胎、闭经、生殖器发育异常、少弱及无精子症等遗传效应,在遗传咨询中应引起足够的重视,对临床诊治工作有重要意义。
Objective To analyze the clinical effects of heterochromatin on reproduction in reproductive subjects. Methods 6958 cases of genital abnormalities by peripheral blood lymphocytes cultured, banding karyotype analysis. Results Detection of chromosomal heterochromatin increased 196 cases, accounting for 2.82% of the patients were seized. Conclusion The increase of heterochromatic region of chromosomes leads to genetic effects such as spontaneous abortion, stillbirth, stillbirth, amenorrhea, genital abnormalities, weakness and azoospermia, which should be paid more attention in genetic counseling and important to clinical diagnosis and treatment significance.