论文部分内容阅读
桥本甲状腺炎又称慢性淋巴细胞性甲状腺炎,是儿童和青少年期最常见的甲状腺病,也是儿童获得性甲状腺功能减低最常见的原因。其特点是甲状腺大,腺体内有弥散性淋巴细胞和浆细胞浸润,间质纤维化和腺体萎缩伴腺泡的嗜酸性退行性变,临床以甲状腺功能减低为特征。近年来对本病的遗传及免疫学机制进行了大量研究,许多概念也发生了变化。现就本病的发生机制和临床诊疗进行综述。
Hashimoto’s thyroiditis, also known as chronic lymphocytic thyroiditis, is the most common thyroid disease in childhood and adolescence and is the most common cause of childhood-acquired hypothyroidism. It is characterized by thyroid gland, diffuse lymphocytes and plasma cells in the gland infiltration, interstitial fibrosis and glandular atrophy with eosinophilic degeneration, clinically characterized by hypothyroidism. In recent years, the genetic and immunological mechanisms of this disease have been extensively studied, and many of the concepts have also changed. The pathogenesis of this disease and clinical diagnosis are reviewed.