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目的:研究冠心病患者颈动脉粥样硬化超声相关参数与病变严重程度的关系,为冠心病的诊断提供依据。方法:选取2015年1月至2016年6月我院收治的冠心病患者100例作为研究组,根据冠状动脉造影结果分为1支病变组(24例),2支病变组(44例)和3支病变组(32例)。根据Gensini评分分为轻度病变组(Gensini评分<20分,n=26),中度病变组(20分≤Gensini评分<40分,n=45)和重度病变组(Gensini评分≥40分,n=29)。另选取同期医院体检的健康体检者30例作为对照组。应用颈动脉超声多普勒检查各组颈动脉超声相关参数,采用Pearson相关性分析超声相关参数与病变严重程度的关系。结果:研究组颈动脉中膜厚度(IMT)、颈总动脉硬化度(β)、颈动脉顺应性(AC)、弹性系数(EP)、脉搏波传导速度(PEVβ)均显著高于对照组,差异有统计学意义(P<0.05)。随着冠状动脉病变支数增加,受试者IMT、β、EP、AC、PEVβ升高,其中3支病变组>2支病变组>1支病变组>对照组(P<0.05)。随着冠状动脉病变程度增加,受试者IMT、β、EP、AC、PEVβ升高,其中重度病变组>中度病变组>轻度病变组>对照组(P<0.05)。经Pearson相关性分析显示:冠心病患者IMT、β、EP、AC、PEVβ与病变血管支数呈正相关(r=0.607,0.428,0.532,0.507,0.556,均P<0.05),与Gensini评分呈正相关(r=0.624,0.432,0.517,0.521,0.543,均P<0.05)。结论:冠心病患者颈动脉粥样硬化超声相关参数与患者病变程度相关,颈动脉超声检查可以作为冠心病的诊断手段。
Objective: To study the relationship between the severity of carotid atherosclerosis and the severity of carotid atherosclerosis in patients with coronary heart disease (CHD) and provide evidence for the diagnosis of coronary heart disease. Methods: From January 2015 to June 2016, 100 patients with coronary heart disease admitted to our hospital were selected as the study group. According to the results of coronary angiography, there were 1 diseased group (24 cases), 2 diseased group (44 cases) and 3 lesions (32 cases). According to the Gensini score, patients were divided into mild lesion group (Gensini score <20 points, n = 26), moderate lesion group (20 points ≤Genini score <40 points, n = 45) and severe lesion group (Gensini score≥40 points, n = 29). Another health examination of the same period the hospital physical examination of 30 cases as a control group. Carotid artery Doppler ultrasound examination of the relevant parameters of carotid ultrasound in each group, using Pearson correlation analysis of ultrasound-related parameters and the severity of the disease. Results: The carotid artery IMT, carotid artery AC, PE, PEVβ in the study group were significantly higher than those in the control group, The difference was statistically significant (P <0.05). The IMT, β, EP, AC and PEVβ levels increased with the increase of the number of coronary artery lesions. Among 3 lesions group, 2 lesions group> 1 lesions group and control group (P <0.05). The levels of IMT, β, EP, AC, PEVβ increased with the severity of coronary artery disease. Among them, severe lesion group> moderate lesion group> mild lesion group> control group (P <0.05). Pearson correlation analysis showed that there was a positive correlation between IMT, β, EP, PE and PEV in patients with coronary heart disease (r = 0.607,0.428,0.532,0.507,0.556, all P <0.05), which was positively correlated with Gensini score (r = 0.624,0.432,0.517,0.521,0.543, all P <0.05). Conclusion: The ultrasound-related parameters of carotid atherosclerosis in patients with coronary heart disease are related to the severity of the disease. Carotid ultrasonography can be used as a diagnostic tool for coronary heart disease.