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氟嗪酸是新的4-喹诺酮类药物,其S-型左旋同分异构体DR-3355,是一种光学异构体,也是广谱高效抗菌药物。作者以临床分离菌测定其最小抑菌浓度(MIC)比氟嗪酸更低,预示抗菌活性高2倍,并探讨其作用机制。一般认为抗菌药物有三种互不相关的作用机制。其一为A机制,主要作用于分裂细胞,抑制RNA和蛋白质合成;其二为B机制,主要作用于非分裂细胞,使之丧失存活能力,抗菌作用表现稍晚;其三称C机制,也是针对非分裂细胞的,如氟啶酸和氟哌酸对细菌作用的方式,抑制DNA旋转酶。
Olanzapine is a novel 4-quinolone drug whose S-type levorotatory isomer DR-3355 is an optical isomer as well as a broad spectrum of highly effective antimicrobial agents. The authors determined that the minimum inhibitory concentration (MIC) of clinical isolates was lower than that of norfloxacin, indicating a 2-fold higher antibacterial activity and its mechanism of action. Antibacterials are generally considered three unrelated mechanisms of action. One is the mechanism of A, the main role in the division of cells, inhibition of RNA and protein synthesis; the second is the B mechanism, the main role in non-dividing cells, so that the loss of viability, antibacterial effect later; third C mechanism, also Against non-dividing cells, such as fluoridic acid and norfloxacin in the role of bacteria, inhibition of DNA gyrase.