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探讨不同的治疗方法对急性重症胆管炎（ACST）并发肺损伤的影响及治疗机制。采用(35)~S标记大肠杆菌为示踪物观察肠道细菌易位；(125)~I标记的牛血清白蛋白测定肺微血管通透性（PMP）；电子自旋共振仪测定组织中氧自由基（OFR）含量；生化方法测定组织中磷脂酶A_2（PLA_2）活性。结果：ACST时肠道内细菌可通过门静脉向肺脏大量易位，诱发肺功能损伤。ACST的PMP显著增加，并与肺组织中OFR和PLA_2水平呈平行关系，提示OFR和PLA_2在肠源性感染造成的肺损伤中发挥重要作用。中药组的治疗效果最佳，而减压组和氨苄组的治疗效果较差甚至会加重组织的功能损伤。作者认为：不同治疗方法对肺功能的影响与其对肠道细菌易位及肺组织中OFR和PLA_2的影响密切相关。
To investigate the different treatment of acute severe cholangitis (ACST) associated with lung injury and treatment mechanism. (35) ~ S labeled E. coli as a tracer to observe intestinal bacterial translocation; (125) ~ I labeled bovine serum albumin measured pulmonary microvascular permeability (PMP); electron spin resonance Free radical (OFR) content; biochemical methods for determination of tissue phospholipase A 2 (PLA 2) activity. RESULTS: Intestinal bacteria in the intestine caused a large number of translocations to the lung via the portal vein during ACST, inducing lung function damage. The PMP of ACST increased significantly and was parallel to the level of OFR and PLA_2 in lung tissue, suggesting that OFR and PLA_2 play an important role in lung injury induced by enterogenous infection. Chinese medicine group the best treatment, and decompression group and amphetamine group of poor treatment even worse functional damage to the organization. The authors believe that the effects of different treatments on lung function are closely related to their effects on intestinal bacterial translocation and OFR and PLA2 in lung tissue.