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乙酰肝素酶是目前发现的哺乳动物细胞中唯一能切割细胞外基质中硫酸乙酰肝素蛋白多糖侧链—硫酸乙酰肝素的一种葡萄糖醛酸内切酶,在肿瘤侵袭转移中起重要作用。本文就乙酰肝素酶的分子结构特点、表达调节及其在胃癌侵袭转移中的作用等方面的研究进展进行综述。
Heparanase is the only glucuronidase in mammalian cells that can cleave heparan sulfate proteoglycan side chain - heparan sulfate in the extracellular matrix, which plays an important role in tumor invasion and metastasis. This review summarizes the molecular structural features, regulation of expression of heparanase and its role in the invasion and metastasis of gastric cancer.