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目的 :研究犬心房颤动 (Af)模型心房有效不应期 (ERP)的变化 ,验证Af电重构这一假说的正确性。方法 :采用快速心房起搏的方法建立犬的Af模型 (起搏组 ,n =13) ,用程序刺激测量心房的ERP ;观察P波时限和PA间期的变化 ,并与假手术组 (对照组 ,n =7)作比较。结果 :持续快速起搏 9～ 10周后 ,心房ERP明显缩短 ,当S1S1为 30 0ms时 ,对照组与起搏组分别为 (15 0± 2 1)ms与 (115± 2 3)ms(P<0 .0 1) ;S1S1为 4 0 0ms时分别为(15 4± 2 4 )ms与 (10 5± 2 7)ms(P <0 .0 1)。起搏组P波时限和PA间期明显长于对照组。结论 :持续心房快速刺激可使ERP明显缩短 ,使心房发生电重构。心房电重构可促进Af的发生和发展
Objective: To study the change of atrial effective refractory period (ERP) in atrial fibrillation (Af) model of canine, and verify the correctness of this hypothesis of Af electrical remodeling. Methods: The canine model of Af was established by rapid atrial pacing (pacing group, n = 13). The atrial ERP was measured by program stimulation. The changes of P wave duration and PA interval were observed and compared with the sham operation group Group, n = 7) for comparison. Results: Atrial ERP was significantly shortened after 9-10 weeks of rapid pacing. When the S1S1 was 30 0ms, the control group and pacemaker group were (15 0 ± 21) ms and (115 ± 23) ms (P <0 .0 1); S1S1 was (154 ± 2 4) ms and (105 ± 2 7) ms respectively at 0 0 ms (P <0.01). Pacing time and P wave PA interval was significantly longer than the control group. Conclusion: Continuous atrial rapid stimulation can significantly shorten the ERP, so that atrial electrical remodeling. Atrial electrical remodeling can promote the occurrence and development of Af