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作者根据现代免疫学观点,自1989年起采用自制中药“90增血剂”治疗ITP46例。期间,应用间接免疫荧光技术检测了患者外周血T淋巴细胞亚群,结果表明病例组全T细胞(CD_3)、T辅助/诱导细胞(CD_4)降低,T抑制/细胞毒细胞(CD_8)增高,CD_4/CD_8比值明显降低。治疗后,患者T亚群恢复常态,血小板数上升,骨髓产板型巨核细胞数增加,临床总有效率达91.2%,明显优于激素组(71.4%)。提示中药具有显著的疗效和良好的免疫调节作用。同时,动态观察ITP患者T细胞亚群的变化,对帮助临床判断治疗反应和预后有很大意义。
According to the modern immunology point of view, since 1989, homemade Chinese medicine “90 hematite” treatment of 46 cases of ITP. Indirect immunofluorescence technique was used to detect the T lymphocyte subsets in peripheral blood of patients. The results showed that the levels of T-lymphocyte / CD_8, CD_3, T-helper / CD_4 / CD_8 ratio decreased significantly. After treatment, T subgroups returned to normal, the number of platelets increased, the number of platelet-producing megakaryocytes increased, the total clinical effective rate was 91.2%, significantly better than the hormone group (71.4%). Prompted Chinese medicine has a significant effect and good immune regulation. At the same time, the dynamic observation of ITP patients with T cell subsets changes, to help clinical judgment of response and prognosis of great significance.