结节性硬化症 (ＴＳ)是一种少见的显性或隐性遗传的先天性疾病[1 ] 。可为家族性、也可散发 ,儿童多见。我们遇到 2例成年患者 ,现报告如下。例 1　男 ,42岁 ,以头痛、失眠来我院就诊。既往史癫痫大发作 2 0年。检查 :神志清楚 ,智力低下 ,鼻翼两侧有多发隆起褐红色坚硬小结节 Tuberous sclerosis (TS) is a rare congenital or dominant inherited disease [1]. Can be familial, but also distributed, children more common. We met two adult patients, are as follows. Example 1 Male, 42 years old, headache, insomnia to our hospital. Past history of epileptic seizures 20 years. Check: Consciousness, mental retardation, multiple nostrils on both sides of the bulge maroon hard nodules