论文部分内容阅读
目的考察当归提取物与不同吸收促进剂对芍药苷在大鼠十二指肠吸收过程的影响,筛选最佳吸收促进剂。方法利用大鼠在体单向肠灌流模型,采用HPLC法测定灌流液中芍药苷含量,分别考察吐温80、羟丙基-β-环糊精、癸酸钠、去氧胆酸钠和当归提取物对吸收的促进作用。结果羟丙基-β-环糊精和当归提取物能显著提高芍药苷的肠道吸收速率,其次是癸酸钠和吐温80,而去氧胆酸钠则没有作用。结论羟丙基-β-环糊精和当归提取物可作为芍药苷口服制剂的吸收促进剂使用,中药当归配伍芍药使用是合理、有效的。
Objective To investigate the effect of Angelica sinensis extract and different absorption enhancers on the absorption process of paeoniflorin in duodenum of rats, and select the best absorption enhancer. Methods The rat model of unilateral intestinal perfusion was established. The content of paeoniflorin in the perfusate was determined by HPLC. Tween 80, hydroxypropyl-β-cyclodextrin, sodium caprate, sodium deoxycholate and Angelica sinensis Extract on the absorption of the promotion. Results Hydroxypropyl-β-cyclodextrin and Angelica sinensis extract could significantly increase intestinal absorption rate of paeoniflorin, followed by sodium caprate and Tween 80, while sodium deoxycholate had no effect. Conclusion Hydroxypropyl-β-cyclodextrin and Angelica extract can be used as absorption enhancer of paeoniflorin oral preparation. It is reasonable and effective to use Angelica sinensis with Radix Paeoniae Alba.