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目的观察以PPl为基础联合三种抗生素的四联疗法治疗幽门螺杆菌感染的根治效果及安全性。方法治疗组给埃索美拉唑20mg,阿莫西林1g,克拉霉素250mg及左氧氟沙星200mg,每日2次服药,对照组给埃索美拉唑20mg,阿莫西林lg,克拉霉素250mg,每日2次服药。疗程均为1周,治疗期间停用其他药物,疗程结束4周后复诊,观察Hp根除率、症状缓解率及不良反应发生率。结果疗程结束4周后复查Hp根除率治疗组为95.2%,对照组为76.7%,两组比较差异有统计学意义(P<0.05);治疗组症状缓解率83.3%,不良反应发生率14.6%,对照组症状缓解率82.6%,不良反应发生率16.7%,无统计学意义(P>0.05)。结论四联疗法可获得较高Hp根治率,疗程短,不良反应少,值得推广临床治疗。
Objective To observe the curative effect and safety of quadruple therapy based on PPl combined with three antibiotics in the treatment of Helicobacter pylori infection. Methods The treatment group was given esomeprazole 20mg, amoxicillin 1g, clarithromycin 250mg and levofloxacin 200mg, 2 times a day, the control group to esomeprazole 20mg, amoxicillin lg, clarithromycin 250mg, Take medicine twice daily. The course of treatment was 1 week. During the treatment period, other drugs were discontinued. After 4 weeks of treatment, the patients were referred for treatment. The eradication rate of Hp, the rate of symptom relief and the incidence of adverse reactions were observed. Results After 4 weeks of treatment, Hp eradication rate was 95.2% in the treatment group and 76.7% in the control group, with significant difference between the two groups (P <0.05). The rate of symptom relief in the treatment group was 83.3% and the incidence of adverse reactions was 14.6% , 82.6% in the control group and 16.7% in the adverse reaction group, with no statistical significance (P> 0.05). Conclusions Quadruple therapy can achieve a higher cure rate of Hp, with short course of treatment and less adverse reactions, so it is worth to promote clinical treatment.