组蛋白乙酰化修饰与基因的表达调控相关,参与了各种肺部疾病的病变过程。组蛋白乙酰化和去乙酰化由一对功能相互拮抗的蛋白酶——组蛋白乙酰基转移酶和组蛋白去乙酰化酶负责。二者之间的动态平衡在特定条件下被破坏,会导致基因转录的失调,引起基因表达的异常。 Histone acetylation and gene expression regulation, involved in a variety of lung disease lesions. Histone acetylation and deacetylation are handled by a pair of proteasomes that are antagonistic to each other, histone acetyltransferase and histone deacetylase. The dynamic balance between the two under the conditions of destruction, can lead to gene transcription disorders, causing abnormal gene expression.