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目的探讨轮状病毒(Rotavirus,RV)肠炎及与乳糖不耐受(Lactose intolerance,LI)之间的相关性。方法前瞻性的纵向观察并随访重庆医科大学附属儿童医院2010年1月至2月收治的52例确诊为RV肠炎的患儿,分成LI组(观察组)28例及非LI组(对照组)24例,比较分析2组之间临床表现及预后。结果观察组及对照组的腹泻次数、脱水程度及腹泻的预后之间的差异没有统计学意义(P>0.05);去乳糖治疗后2组的腹泻次数均有显著性减少(P<0.01),但去乳糖3 d后观察组的腹泻次数比对照组多(P<0.05)。结论 LI对RV肠炎临床表现及预后没有明显的影响,在RV肠炎急性期去乳糖治疗的价值有限,益生菌可能有助于急性腹泻的缓解。
Objective To investigate the relationship between rotavirus (RV) enteritis and lactose intolerance (LI). Methods A prospective longitudinal observation and follow-up of 52 children with RV enteritis admitted to Children’s Hospital of Chongqing Medical University from January to February 2010 were divided into LI group (observation group) and non-LI group (control group) Twenty-four patients were analyzed for clinical manifestations and prognosis. Results There was no significant difference in the number of diarrhea, the degree of dehydration and the prognosis of diarrhea between the observation group and the control group (P> 0.05). The number of diarrhea in the two groups after treatment was significantly decreased (P <0.01) However, after 3 days of lactose treatment, the number of diarrhea in observation group was more than that in control group (P <0.05). Conclusion LI has no obvious effect on the clinical manifestations and prognosis of RV enteritis, and its value in the treatment of RV enteritis is limited. Probiotics may contribute to the relief of acute diarrhea.