论文部分内容阅读
目的观察布地奈德福莫特罗联合小剂量阿奇霉素控制哮喘发作的临床效果。方法将80例中度哮喘急性发作患者随机分为观察组和对照组各40例。对照组给予布地奈德福莫特罗治疗,观察组在对照组基础上加阿奇霉素口服,2组均维持治疗12周。观察2组疗效、肺功能和IgE水平的变化。结果治疗过程中对照组退出2例。观察组完全控制率为87.5%高于对照组的68.4%,差异有统计学意义(P<0.05)。治疗前2组第1秒用力呼气容积占预计值百分比(FEV1%)、最大呼气流量占预计值百分比(PEF%)及IgE水平差异无统计学意义(P>0.05)。治疗后2组肺功能指标均有明显改善,IgE水平均下降,且观察组改善更明显,差异均有统计学意见义(P<0.05)。结论应用布地奈德福莫特罗联合小剂量阿奇霉素治疗哮喘可以更有效地控制哮喘发作,改善肺功能,同时降低IgE水平,值得推广应用。
Objective To observe the clinical efficacy of budesonide formoterol in combination with low dose azithromycin in the control of asthma attacks. Methods Eighty patients with moderate exacerbation of asthma were randomly divided into observation group (40 cases) and control group (40 cases). The control group was treated with budesonide formoterol. The observation group was treated with azithromycin orally on the basis of the control group, and the two groups were maintained for 12 weeks. The curative effect, lung function and IgE level in the two groups were observed. Results During the treatment, the control group exited in 2 cases. The complete control rate of the observation group was 87.5% higher than that of the control group (68.4%), the difference was statistically significant (P <0.05). Before the treatment, the forced expiratory volume of the first second was the predicted percentage (FEV1%), the maximum expiratory flow was not statistically different from the predicted percentage (PEF%) and the IgE level (P> 0.05). After treatment, both groups had significant improvement of pulmonary function indexes, IgE levels decreased, and the observation group improved more obviously, the difference was statistically significant (P <0.05). Conclusions The combination of budesonide formoterol and low-dose azithromycin in the treatment of asthma can effectively control asthma attacks, improve lung function and reduce IgE level, which is worthy of promotion and application.