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五灵丸能明显降低SD人鼠用D-氨基乳糖引起的SGPT和SGOT增高,分别由1284±235nmol/s和3171±379nmol/s降至691±119nmol/s(4500mg/kg组),824±93nmol/s(2250mg/kg组)和1848±331nmol/s(4500mg/kg组).1950±331nmol/s(2250mg/kg组); 并能降低血清胆固醇和甘油三酯,分别由2.02±0.46mmol/L和0.74±0.11mmol L降至1.64±0.25mmol L.1.59±0.19mmol/L和0.48±0.08mmol/L,0.54±0.08mmol/L,提高血中白蛋白 球蛋白的比值,分别由1.22±0.16和1.12±0.48升至2.04±0.33和2.12±0.40.组化与越显微结构揭示.治疗组肝细胞基本完整,胞质丰满,RNA、肝糖原增加,线粒体边缘清晰,粗面内质网正常,滑面内质网增加.结果提示:五灵丸对D-氨基乳糖受损的大鼠肝细胞有明显的修复作用.
Wuling Pill can significantly reduce the increase of SGPT and SGOT induced by D-amino lactose in SD humans, and decreased from 1284±235 nmol/s and 3171±379 nmol/s to 691±119 nmol/s (4500 mg/kg group), respectively. 93nmol/s (2250mg/kg group) and 1848±331nmol/s (4500mg/kg group). 1950±331nmol/s (2250mg/kg group); and can reduce serum cholesterol and triglyceride by 2.02±0.46mmol, respectively The ratio of /L and 0.74±0.11 mmol L to 1.64±0.25 mmol L.1.59±0.19 mmol/L and 0.48±0.08 mmol/L, and 0.54±0.08 mmol/L, respectively, increased blood albumin ratio by 1.22, respectively. ± 0.16 and 1.12 ± 0.48 increased to 2.04 ± 0.33 and 2.12 ± 0.40. Histochemistry and ultrastructure revealed that the treated group was basically complete with hepatocytopenia, RNA, hepatic glycogen increased, and mitochondrial margins were clear. Normal plasmon reticulum and smooth endoplasmic reticulum increased. The results suggest that Wuling Pill has obvious repairing effect on D-amino lactose-damaged rat hepatocytes.