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目的 :探讨中药制剂“阻育丸”对雌性 SD大鼠的绝育效果。方法 :对同组 SD大鼠进行自身对比观察。根据祖传秘方(单方 )制成中药制剂“阻育丸”。选择 4月龄雌性 SD大鼠 40只 ,根据阴道涂片检查结果 ,确定动情周期 1次顿服“阻育丸”3 .75 g/ kg体重 ,并将 SD大鼠雌雄按 3∶ 1比例合笼 ,将服药前及服药后妊娠百分率及每次妊娠胚胎数进行比较。结果 :服用“阻育丸”后 ,妊娠率由服药前的 10 0 %下降为 12 .5 %,绝育率达 87.5 %,每次妊娠胚胎数由服药前平均 10 .75胎 /次 ,下降为平均 2 .3 4胎 /次。结论 :“阻育丸”在绝育方面是一种较安全、方便、价廉、有效的药物 ,值得进一步研究和推广应用。
Objective: To investigate the sterilizing effect of traditional Chinese medicine “block pills” on female SD rats. Methods: The same group of SD rats self-contrast observation. According to ancestral recipe (unilateral) made of traditional Chinese medicine preparation “block pills.” Forty female 4-month-old female Sprague-Dawley rats were selected. According to the result of vaginal smear test, the ovulation test block was determined to be 3.75 g / Cage, before taking and after taking the percentage of pregnancy and the number of embryos per pregnancy were compared. Results: After taking “block pills”, the pregnancy rate decreased from 10% before taking medicine to 12.5% and the sterilization rate reached 87.5%. The number of embryos per pregnancy dropped from Average 2.3years. Conclusion: The pill is a safe, convenient, cheap and effective drug in sterilizing, which deserves further research and popularization and application.