增强抑制实验是通过比较鲎试剂在已知含量内毒素水溶液中的反应和在相同内毒素含量的样品溶液中的反应,观察样品对鲎试剂的增强或抑制作用,从而判断样品是否适宜用鲎试剂作细菌内毒素的检查.增强抑制实验中的最大有效稀释(MVD)适合于注射液或以非经胃肠道给药的溶解液或稀释液,以及给药剂量按重量计而给药体积可以适当变化的药品,其计算公式为:MVD=E·P/λ,其中E为样品的细菌内毒素限量, Enhancement inhibition test is by comparing the reaction of 鲎 reagent in aqueous solution of endotoxin with known content and the reaction in the sample solution with the same endotoxin content to observe the enhancement or inhibition effect of the sample on 鲎 reagent so as to judge whether the sample is suitable for using 鲎 reagent Bacterial endotoxins. Maximum Effective Dilution (MVD) in Enhanced Inhibition Assay Dissolution solutions or dilutions suitable for injection or parenteral administration, as well as dosing volumes administered by weight, may be administered Appropriate changes in the drug, which is calculated as: MVD = E · P / λ, where E is the bacterial endotoxin limit of the sample,