扩张型心肌病心肌细胞膜β受体数目减少,对β受体激动剂的正性变力作用效应进行性迟钝,并与心功能严重程度相一致。晚期患者,心肌腺苷酸环化酶活性下降。α_1受体、磷酸肌醇代谢和免疫机制可能参与调控β受体功能。腺苷酸环化酶催化亚单位和蛋白激酶激动剂对纠正晚期心功能不全可能具有治疗意义。 Dilated cardiomyopathy myocardial cells decreased the number of β receptors, β receptor agonists positive force effect of sexual retardation, and consistent with the severity of cardiac function. Late patients, myocardial adenylate cyclase activity decreased. α_1 receptor, phosphoinositide metabolism and immune mechanisms may be involved in the regulation of β-receptor function. Adenylate cyclase catalytic subunits and protein kinase agonists may be of therapeutic value in correcting late cardiac insufficiency.