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黄连解毒汤提取物能明显降低酵母所致的大鼠体温升高;对二甲苯所致小鼠耳壳肿胀和醋酸所致小鼠腹腔毛细血管通透性升高均有显著抑制作用;单次给予家免后能明显抑制实验性血栓形成和ADP诱导的血小板聚集,作用呈剂量依赖性。此外,黄连解毒汤提取物可明显延长小鼠断头后的喘气时间,并使急性脑缺血大鼠脑含水量和过氧化脂质显著降低,超氧化物歧化酶活力升高。
The extract of Huanglian Jiedu Decoction can significantly reduce the increase in body temperature of rats induced by yeast; it also has a significant inhibitory effect on the swelling of the ear shell of mice induced by xylene and the increase of capillary permeability of the abdominal cavity of mice induced by acetic acid; After home-administration, it can significantly inhibit experimental thrombosis and ADP-induced platelet aggregation in a dose-dependent manner. In addition, Huanglian Jiedu Decoction extract can significantly prolong the gasping time after decapitation in mice, and significantly reduce cerebral water content and lipid peroxidation in rats with acute cerebral ischemia, and increase the activity of superoxide dismutase.