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目的评价宫颈薄层液基细胞学(liquid-based cytololgy test,LCT)和人乳头瘤病毒(Human papillomavirus,HPV)DNA配合阴道镜检查在宫颈病变筛查中的应用价值。方法选取就诊梅州市人民医院行宫颈检查的患者,以病理结果作为金标准,评价宫颈薄层液基细胞学检查和PCR扩增,基因探针杂交方法检查人乳头廇病毒在临床的应用价值。结果 HPV DNA和LCT均阳性的患者中,随着TBS细胞学诊断的级别升高分别为SCC97.4%、CINⅢ92.3%、CINⅡ83.4%、CINⅠ71.8%。结论采用LCT结合HPV DNA检查可以提高宫颈上皮内瘤样变(宫颈癌前病变)的阳性诊断率,可疑患者应配合阴道镜检查及镜下活检进一步明确诊断及治疗,重视宫颈癌前病变的规范化筛查。
Objective To evaluate the value of cervical cytology-based cytololgy test (LCT) and human papillomavirus (HPV) DNA with colposcopy in the screening of cervical lesions. Methods The patients who underwent cervix examination in Meizhou People’s Hospital were enrolled. The pathological results were used as the gold standard to evaluate the clinical value of cervical smear-based cytology and PCR amplification and gene probe hybridization in detecting human papillomavirus. Results Among the patients with positive HPV DNA and LCT, the level of cytological diagnosis of SCC was 97.4%, 92.3%, 83.4% and 83.1%, respectively. Conclusion LCT combined with HPV DNA test can improve the positive rate of cervical intraepithelial neoplasia (cervical precancerous lesions), suspicious patients should be combined with colposcopy and microscopic biopsy to further confirm the diagnosis and treatment, emphasis on precancerous lesions of the cervix Screening.