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目的：了解神经系统衰老的一些特征性变化。方法：对取自不同年龄组动静脉畸形或动脉瘤病人的脑皮层标本进行了电镜检查。结果：在老年组，神经元固缩、核糖体解聚、胞浆内出现大量脂滴及脂褐素颗粒、染色质凝聚。胶质细胞胞体及突起肿胀、胞浆空化、突触减少、轴索内神经微丝溶解。结论：脑衰老的这些改变与早老性痴呆的改变相比只是量的改变而非质的变化
Objective: To understand some of the characteristic changes of the nervous system aging. METHODS: Electron microscopy was performed on cortical specimens from patients of different age groups with arteriovenous malformations or aneurysms. Results: In the aged group, neurons were pyknotic, ribosome disaggregated, lipid droplets and lipofuscin granules appeared in the cytoplasm, and chromatin was aggregated. Glial cell body and processes swelling, cytoplasmic cavitation, synapses decreased axonal neurofilament lysis. CONCLUSIONS: These changes in brain aging are only quantitative changes rather than qualitative changes compared to changes in Alzheimer’s disease