【摘 要】
:
BACKGROUND AND OBJECTIVEWhile studies have shown cirrhosis to be associated with extrahepatic hemorrhagic and thrombotic processes, the cerebrovascular complications of cirrhosis are not well understo
论文部分内容阅读
BACKGROUND AND OBJECTIVEWhile studies have shown cirrhosis to be associated with extrahepatic hemorrhagic and thrombotic processes, the cerebrovascular complications of cirrhosis are not well understood. This study assessed the association between cirrhosis and various stroke subtypes.
METHODSThis retrospective cohort study included 1,618,059 Medicare beneficiaries treated between 2008 and 2014. From the records, treatment for cirrhosis or its complications were identified. Additionally, the data were reviewed for hospital admission for any stroke, with secondary outcomes including ischemic stroke intracerebral hemorrhage, and subarachnoid hemorrhage.
RESULTSOf the patients reviewed, 15,586 were diagnosed with cirrhosis with an average age of 74.1 years. During a mean follow-up of 4.3 years, 77,268 were hospitalized with stroke. The incidence of stroke was 2.17% among patients with cirrhosis and 1.11% for those without. After adjusting for demographic characteristics, stroke risk factors and comorbidities, patients with cirrhosis experienced a higher risk of any stroke (HR 1.4). This association was higher for intracerebral hemorrhage (1.9) and subarachnoid hemorrhage (2.4) than for ischemic stroke.
CONCLUSIONThis study of elderly patients found that cirrhosis is associated with an increased risk of stroke, particularly hemorrhagic stroke.
其他文献
目的探讨淋巴结细针抽吸活检(FNA)洗脱液EB病毒(EBV)-DNA浓度测定对鼻咽癌颈部淋巴结转移的诊断价值。方法选取2016年8月至12月在中山大学肿瘤防治中心病理确诊为鼻咽癌的患者36例及非EBV相关的其他肿瘤患者9例,所有患者行头颈部MRI、血清和颈部淋巴结FNA洗脱液EBV-DNA检测。结果淋巴结EBV-DNA检测中位浓度(1.39×105 copies/ml)高于血清EBV-DNV检测中
约80%的胰腺癌患者会发生葡萄糖代谢的改变,表明糖尿病与胰腺癌的发生发展存在关联。有研究表明糖尿病及降糖药与胰腺癌的发生风险、临床表现及预后密切相关。目前研究发现,胰岛素抵抗、高胰岛素血症、胰岛素样生长因子相关蛋白的表达水平及炎症反应等是糖尿病与胰腺癌相互影响的可能机制,但其确切机制仍不明确,仍需进一步深入研究。
液体活检是一类热门且新兴的病理检测技术,主要包括肿瘤循环细胞检测、肿瘤循环DNA检测以及外泌体检测,近年来研究显示该技术不仅在胰腺癌早期诊断中发挥着潜在的优势,而且对肿瘤的预后判断以及复发监测有一定的指导意义。
目的探讨CD68与含自水解酶域蛋白5(ABHD5)在胃癌组织中的表达及其与胃癌患者临床病理特征之间的关系以及两者的相关性。方法采用免疫组织化学法检测CD68及ABHD5蛋白在60例胃癌组织及30例癌旁正常组织中的表达情况,分析二者与胃癌患者临床病理特征的关系及二者的相关性。结果CD68在胃癌组织和癌旁正常组织中的阳性表达率分别为65.00%、26.67%,差异有统计学意义(χ2=11.779,P=
目的观察本体感觉神经促进技术(PNF)联合核心稳定性训练对功能性踝关节不稳(FAI)患者下肢功能康复的影响。方法选取FAI患者20例,按随机数字表法分为实验组和对照组,每组患者10例。2组患者均采用常规康复训练,对照组在此基础上增加踝关节肌力训练和本体感觉训练;实验组则在常规康复训练的基础上增加PNF联合核心稳定性训练。2组患者均于治疗前和治疗12次后(治疗后)采用Cumberland踝关节不稳定
目的观察基于控制性运动的脊柱稳定训练治疗护理人员慢性非特异性腰痛的临床疗效。方法选取某三级甲等医院慢性非特异性腰痛在职护士29例。在康复知识宣教、姿势调整、局部扳机点压力治疗等基础上给予基于控制性运动的脊柱稳定训练,并辅以有意识腹肌提前收缩(VPAC)干预。于治疗前、治疗12周后及治疗结束随访8周时分别采用疼痛视觉模拟评分法(VAS)、Oswestry残疾指数(ODI)对患者疗效进行评定。结果本研
目的利用静息态功能磁共振成像技术(Rs-fMRI)研究维族和汉族脑卒中失语症患者在静息态下脑自发活动的差异区,并初步探讨形成差异的原因。方法利用Rs-fMRI采集15例汉族脑卒中失语症患者(汉语组)和12例维族脑卒中失语症患者(维语组)静息态下的fMRI数据,对数据预处理后进行低频振幅(ALFF)指标的计算,最后对两组数据做组间统计学比较。结果静息状态下汉语患者的ALFF大于维语患者,汉语患者的右
BACKGROUND AND OBJECTIVEFor patients with acute ischemic stroke, early intensive rehabilitation therapy is recommended by the Veterans Affairs/Department of Defense Clinical Practice Guidelines. This