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BACKGROUND AND OBJECTIVEWhile studies have shown cirrhosis to be associated with extrahepatic hemorrhagic and thrombotic processes, the cerebrovascular complications of cirrhosis are not well understo
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BACKGROUND AND OBJECTIVEWhile studies have shown cirrhosis to be associated with extrahepatic hemorrhagic and thrombotic processes, the cerebrovascular complications of cirrhosis are not well understood. This study assessed the association between cirrhosis and various stroke subtypes.
METHODSThis retrospective cohort study included 1，618，059 Medicare beneficiaries treated between 2008 and 2014. From the records, treatment for cirrhosis or its complications were identified. Additionally, the data were reviewed for hospital admission for any stroke, with secondary outcomes including ischemic stroke intracerebral hemorrhage, and subarachnoid hemorrhage.
RESULTSOf the patients reviewed, 15，586 were diagnosed with cirrhosis with an average age of 74.1 years. During a mean follow-up of 4.3 years, 77，268 were hospitalized with stroke. The incidence of stroke was 2.17% among patients with cirrhosis and 1.11% for those without. After adjusting for demographic characteristics, stroke risk factors and comorbidities, patients with cirrhosis experienced a higher risk of any stroke (HR 1.4). This association was higher for intracerebral hemorrhage (1.9) and subarachnoid hemorrhage (2.4) than for ischemic stroke.
CONCLUSIONThis study of elderly patients found that cirrhosis is associated with an increased risk of stroke, particularly hemorrhagic stroke.
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