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目的探讨长骨釉质瘤的临床病理特征、诊断与鉴别诊断及其组织发生。方法对1例长骨釉质瘤进行病理形态学观察及免疫组化分析。结果长骨釉质瘤的特征性改变为兼具上皮样细胞和纤维样梭形细胞2种成分,两者以不同的比例和形态相互交织排列。免疫组化示上皮样细胞CK、CK5和CK19(+),CK7和CK8/18(-);梭形细胞vimentin(+),bcl-2和CD99均(-)。结论长骨釉质瘤为双向分化的低度恶性肿瘤,形态多样,需结合肿瘤的组织形态和免疫组化特点对其进行诊断与鉴别诊断。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of long bone enamel tumor and its histological appearance. Methods One case of long bone enamel was observed by histopathology and immunohistochemistry. Results The characteristic changes of long bone enamel tumors were the two components of epithelial-like cells and fibro-like spindle cells, which were interlaced with different proportions and morphologies. Immunohistochemistry showed epithelial cells CK, CK5 and CK19 (+), CK7 and CK8 / 18 (-); spindle cells vimentin (+), bcl-2 and CD99 were all (-). Conclusion Long bone enamel tumor is a low-grade malignant tumor with two-way differentiation. It has various forms and needs to be diagnosed and differentiated according to its histomorphology and immunohistochemical characteristics.