胶质瘤是最常见的原发性脑肿瘤,由于它具有无限制增生,缺乏凋亡等特性,使得手术及放化疗等方法难以取得令人满意的疗效,近年来,在基因水平积极研究胶质瘤的治疗方法是当前神经外科领域前沿课题。随着纳米技术的发展和分子生物学水平的提高,利用具有特别跨膜传递功能、在人体内可生物降解的、可控制释放的复合功能性的纳米载体对脑肿瘤进行基因治疗已成为国内外研究的热点。 Glioma is the most common primary brain tumor. Because of its characteristics of indefinite hyperplasia and lack of apoptosis, glioma is difficult to obtain satisfactory results in surgery and chemoradiotherapy. In recent years, glioma has been actively studied at the gene level Tumor treatment is currently the forefront of neurosurgical issues. With the development of nanotechnology and the improvement of molecular biology, the gene therapy of brain tumor using nanocarriers with special transmembrane transfer function, biodegradable and controlled release in the human body has become a worldwide challenge Hot research.