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目的:探讨妊娠糖尿病患者血清脂联素和TNF-α水平的变化,研究其与胰岛素抵抗的关系。方法:选取12名妊娠糖尿病患者和20名正常妊娠妇女作为研究对象。测定受试者血浆脂联素和TNF-α水平,比较脂联素和TNF-α水平的关系,分析两者与胰岛素抵抗指数的相关性。结果:妊娠期糖尿病患者脂联素水平下降(P<0.05),TNF-α水平升高(P<0.05),脂联素与TNF-α呈负相关(r为0.32,P<0.05);脂联素与IR呈负相关(r为0.41,P<0.05);TNF-α与IR呈正相关(r为0.36,P<0.05);结论:妊娠糖尿病患者血清脂联素升高,同时TNF-α水平下降,两者与胰岛素抵抗有着密切的关系。
Objective: To investigate the changes of serum adiponectin and TNF-α in patients with gestational diabetes mellitus, and to study the relationship between them and insulin resistance. Methods: Twelve patients with gestational diabetes mellitus and 20 normal pregnant women were selected as the study subjects. The plasma adiponectin and TNF-α levels were measured and the relationship between adiponectin and TNF-α levels was compared. The correlation between them and insulin resistance index was analyzed. Results: The level of adiponectin in pregnant women with gestational diabetes mellitus decreased (P <0.05), the level of TNF-α increased (P <0.05) and the level of adiponectin was negatively correlated with TNF-α (r = 0.32, P <0.05) The level of TNF-α was positively correlated with IR (r = 0.36, P <0.05). CONCLUSION: Serum adiponectin is elevated in gestational diabetes mellitus patients with TNF-α Decline, both with insulin resistance has a close relationship.