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探讨了盐酸苯海拉明在适当的酸性条件下与锌试剂、铜离子定量生成三元络合物 ,经 MIBK萃取 ,以 AAS法测定萃取液中的铜来间接测定盐酸苯海拉明的量。本法与药典法相比 ,相对平均偏差小于 0 .4% ,线性范围为 5～ 50μg· m L-1,回收率为 97%～ 1 0 2 %。
The diphenhydramine hydrochloride was quantified to produce ternary complex with zinc reagent and copper ion under appropriate acidic conditions. The amount of diphenhydramine hydrochloride was determined indirectly by MIBK extraction and the copper in the extract was determined by AAS method . Compared with the pharmacopoeia, the relative average deviation of this method is less than 0.4%, the linear range is 5 ~ 50μg · m L-1, and the recovery rate is 97% ~ 102%.