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目的分析2012年和2013年1月至11月期间引起深圳市南山区手足口病的病原组成情况以及不同病原引起的临床症状的差异,及早了解手足口病病原最新的流行情况,科学预防病原变异,并通过比较手足口病初发时临床症状,预测疾病的发展趋势,以期预防手足口病重症的发生。方法分析2012年和2013年1月至11月本区采集的手足口病集中爆发疫情中的病原检测资料和流行病学调查资料,总结疫情暴发情况与季节的关系和由不同病原引起的临床症状。结果不同病原在不同季节的流行情况不同,EV71和CoxA16主要在1~6月流行,除这两病毒外的其它肠道病毒主要在4~12月流行,其中4~6月感染的病例数最多。而不同病原引起的临床症状差异,最主要表现为由EV71和CoxA16引起的症状轻微的手足口病很少出现发热和咽炎,而除这两种病毒外的肠道病毒引起的手足口病表现为发热、咽炎和咳嗽。结论由非EV71非CoxA16的肠道病毒感染的87.0%的病例出现咽炎,本区非EV71非CoxA16的肠道病毒阳性病例很可能感染的是CoxA 6,相关证实及研究正在进行中。
Objective To analyze the pathogenic components of hand-foot-mouth disease and the clinical symptoms caused by different pathogenic agents in Nanshan District, between January 2012 and January 2013, and to find out the latest epidemic situation of hand-foot-mouth disease and to prevent the pathogenic mutation , And by comparing the clinical symptoms of HFMD at the first attack, predict the development trend of the disease, in order to prevent the occurrence of HFMD. Methods The pathogen detection data and epidemiological survey data of HFMD outbreaks collected in this area from January to November 2013 were analyzed in 2012 and from January to November 2013, and the relationship between the outbreak of the epidemic situation and the season and the clinical symptoms caused by different pathogens were summarized . Results The prevalence of different pathogens in different seasons was different. EV71 and CoxA16 mainly occurred in 1 ~ 6 months. Other than these two viruses, other enteroviruses were predominant in 4 ~ 12 months, of which 4 to 6 months were the most . The clinical symptoms caused by different pathogenic differences, the most important manifestation of mild symptoms of EV71 and CoxA16 hand-foot-mouth disease fever and pharyngitis rarely occur, and in addition to these two viruses enterovirus-induced hand-foot-mouth disease manifested as Fever, pharyngitis and coughing. Conclusions Pharyngitis occurs in 87.0% of cases infected with enterovirus other than EV71 non-CoxA16. The positive cases of non-EV71 non-CoxA16 enterovirus in this area are likely to be infected with CoxA6. Relevant findings and studies are underway.