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磺胺醋酰钠滴眼剂的含量测定,药典采用永停滴定法。该法需特殊设备,普及上受到限制。我们根据中和法的原理,采用电位法测定磺胺醋酰钠滴眼剂的含量,以反对数作图法(Gran作图法)确定等当点。此法不需特殊设备(有一酸度计即可),操作也较简便实验结果证明该法较为准确可靠。仪器与试药 PHS—2A型精密酸度计,永停滴定仪,按药典方法装置。自制磺胺醋酰钠滴眼剂(每100ml含磺胺醋酰钠10.0g,尼泊金乙酯0.03g硫代硫酸钠0.1g);0.1mol/L盐酸液。测定方法取105℃干燥至恒重的磺胺醋酰钠约10g,精密称定;置100ml量瓶中,加水溶解并稀释
Sulfasalate sodium eye drops content determination Pharmacopoeia Yong stop titration. The law requires special equipment, universal access is limited. According to the principle of neutralization, we measured the content of sulfasalate sodium eye drops by the potentiometric method and determined the equivalent points by the method of anti-logarithmic mapping (Gran-plot method). This method does not require special equipment (an acid meter can be), the operation is relatively simple Experimental results show that the law is more accurate and reliable. Instruments and reagents PHS-2A-type precision acidimeter, stop titration, according to the Pharmacopoeia method device. Self-made sodium sulfasalate eye drops (100ml each containing sodium sulfamyl sodium 10.0g, ethyl paraben 0.03g sodium thiosulfate 0.1g); 0.1mol / L hydrochloric acid solution. Determination of Take 105 ℃ dried to constant weight sulfonamide sodium about 10g, accurately weighed; set 100ml flask, dissolved in water and diluted