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目的探讨缺血再灌注家兔白细胞变形能力（ＬＤ）的变化及６５４－２对其影响。②方法采用结扎／放开冠状动脉左旋支造成家兔急性心肌缺血再灌注模型，采用ＤＸＣ－３００Ａ型核孔膜红细胞变形能力测定仪检测了ＬＤ和血浆总超氧化物歧化酶（ＳＯＤ）活力的变化。③结果缺血再灌注组家兔ＬＤ与ＳＯＤ均明显降低，与对照组、缺血组比较，差异有极显著性（Ｆ＝２１．７６，１８．９２，ｑ＝８．５２～１７．０８，Ｐ＜０．０１）。应用６５４－２治疗后，ＬＤ与ＳＯＤ均升高，与缺血再灌注组比较，差异有极显著性（ｑ＝９．２６，８．７６，Ｐ＜０．０１）；与对照组比较差异无显著性（ｑ＝１．５２，２．０６，Ｐ＞０．０５）。缺血再灌注组、缺血组和６５４－２组家兔ＬＤ与ＳＯＤ呈正相关（ｒ＝０．８２３～０．８８４，Ｐ＜０．０１）。④结论急性心肌缺血再灌注家兔ＬＤ明显降低，６５４－２具有增强ＬＤ的作用
Objective To investigate the changes of leukocyte deformability (LD) in rabbits with ischemia / reperfusion and the effect of 654-2 on it. Methods The acute myocardial ischemia-reperfusion model was induced by ligation and release of left circumflex coronary artery in rats. DXC-300A erythrocyte deformability was used to detect the activity of LD and total superoxide dismutase (SOD) The change. Results The LD and SOD of rabbits in ischemia-reperfusion group were significantly lower than those in control group and ischemia group (F = 21.76, 18.92, q = 8.52-17.08 , P <0.01). After treatment with 654-2, the levels of LD and SOD increased, compared with the ischemia-reperfusion group, the difference was significant (q = 9.26, 8.76, P <0.01); compared with the control group No significant (q = 1.52,2.06, P> 0.05). There was a positive correlation between LD and SOD in ischemia / reperfusion group, ischemia group and 654-2 group (r = 0.823-0.884, P <0.01). ④ Conclusion Rabbit acute myocardial ischemia reperfusion was significantly reduced LD, 654-2 has an enhanced LD