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目的探讨1例真菌性足菌肿的临床病理特点、诊断、治疗及预后,并对其致病菌进行鉴定。方法分析我科收治的1例下颌部真菌性足菌肿的临床及病理特点,进行真菌学及分子生物学鉴定。结果该患者以下颌部肿胀、多发窦道形成、排大量黑色颗粒为主要症状,病理检查示化脓性肉芽肿性炎症,PAS染色可见大量藕节状真菌菌丝。ITS1、ITS2和D1/D2区测序结果示:病原菌与足菌肿马杜拉分支菌有最大的相似性,但相似性小于97%。结论本病例为发生在下颌部的由马杜拉分支菌属内一新的菌种引起的真菌性足菌肿。
Objective To investigate the clinicopathological features, diagnosis, treatment and prognosis of 1 fungal pedunculosis and to identify its pathogenic bacteria. Methods The clinical and pathological features of 1 fungal mycosis pedicle in our department were analyzed for mycological and molecular biological identification. Results The patient had swelling of the lower jaw, multiple sinus formation, a large number of black granules as the main symptom, pathological examination showed purulent granulomatous inflammation, PAS staining showed a lot of lotus-like fungi mycelium. Sequencing results of ITS1, ITS2 and D1 / D2 showed that there was the largest similarity between pathogen and mycoplasma subsp. Madidula, but the similarity was less than 97%. Conclusions This case is a fungal mycosis caused by a new strain of the genus Mudra in the lower jaw.