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目的:探讨VEGF-C和MMP-9在大肠癌中的表达及其意义。方法:利用免疫组化技术检测组织芯片(包括110例大肠癌组织和20例癌旁正常组织)中VEGF-C及MMP-9的表达。结果:VEGF-C和MMP-9在大肠癌中表达的阳性率分别为82.7%和80.0%,明显高于两者在癌旁正常组织中的表达(5.0%,10.0%)(P<0.05)。VEGF-C和MMP-9在Dukes C/D期大肠癌中表达的阳性率分别为90.7%和88.9%,明显高于两者在Dukes A/B期大肠癌中的表达(73.2%,69.6%)(P<0.05)。在大肠癌组织中,VEGF-C与MMP-9的阳性表达呈低度正相关(r=0.253,P<0.05)。结论:VEGF-C和MMP-9的表达与大肠癌的发生发展及浸润转移密切相关,两者的高表达提示大肠癌恶性程度较高。
Objective: To investigate the expression of VEGF-C and MMP-9 in colorectal carcinoma and its significance. Methods: The expression of VEGF-C and MMP-9 in tissue microarray (including 110 cases of colorectal carcinoma and 20 cases of adjacent normal tissues) was detected by immunohistochemistry. Results: The positive rates of VEGF-C and MMP-9 in colorectal carcinoma were 82.7% and 80.0%, respectively, which were significantly higher than those in normal tissues (5.0% and 10.0%, P <0.05) . The positive rates of VEGF-C and MMP-9 in Dukes C / D colorectal cancer were 90.7% and 88.9%, respectively, which were significantly higher than those in Dukes A / B colorectal cancer (73.2%, 69.6% ) (P <0.05). In colorectal cancer, the positive expression of VEGF-C and MMP-9 had a low positive correlation (r = 0.253, P <0.05). Conclusion: The expressions of VEGF-C and MMP-9 are closely related to the carcinogenesis, invasion and metastasis of colorectal cancer. The high expression of VEGF-C and MMP-9 may indicate that the malignant degree of colorectal cancer is high.