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美《肠道》杂志第20期(1979年)第865页报道W.G.Davis等人著文:用生物学测定法测定了正常结肠、结肠腺癌、盲肠癌、正常和发炎的阑尾中的亮氨酸和蛋氨酸脑啡肽。在腺癌和发炎的阑尾内蛋氨酸脑啡肽的水平较正常对比组显著为高。亮氨酸脑啡肽水平无显著改变。盲肠肿瘤有退行发育,但未含有可证明为类鸦片样的活性。
WG Davis, et al., Writing in the American Journal of Intestines, 20 (1979), page 865: Determination of leucine in normal colon, colon adenocarcinoma, colorectal cancer, normal, and inflamed appendix by biological assays Acid and methionine enkephalin. The levels of adenocarcinoma and inflamed intrinsic methionine enkephalin were significantly higher than those in the normal control group. There was no significant change in leucine-enkephalin levels. The cecal tumors have degenerative development but no evidence of opioid-like activity.