肝静脉闭塞病(VOD)是移植早期出现的严重并发症,早期的诊断治疗对高危患者非常重要。既往人们的诊断主要局限于临床和影像学,近几年来,血液学的检查尤其是纤溶酶原活化物抑制物-1和透明质酸对于VOD的早期诊断,低分子量肝素对VOD的预防性应用与去纤苷对重度VOD的治疗日益受到重视。本文主要就当前VOD的诊断、预防和治疗的新进展进行了综合的论述。 Hepatic veno-occlusive disease (VOD) is a serious complication in the early stages of transplantation. Early diagnosis and treatment are very important for high-risk patients. In the past, the diagnosis was mainly confined to clinical and radiological studies. In recent years, hematological examinations, especially plasminogen activator inhibitor-1 and hyaluronic acid, have been used for the early diagnosis of VOD and for the prevention of VOD by low molecular weight heparin Application and de-glycosides on the treatment of severe VOD has received increasing attention. This article focuses on the current VOD diagnosis, prevention and treatment of the new progress made a comprehensive discussion.