论文部分内容阅读
目的:探讨脑梗死患者血清中炎性细胞因子水平与病情严重程度的关系。方法:收集2006-01/2008-12脑梗死患者82例为研究组,80例同期门诊体检的健康人为对照组,检测其外周血清中肿瘤坏死因子α(TNF-α)、白细胞介素1β(IL-1β)和可溶性细胞间黏附分子1(sICAM-1)水平。结果:急性期、恢复期脑梗死患者血清IL-1β、TNF-α及sI-CAM-1水平均较对照组显著增高(P<0.01或P<0.05),脑梗死组急性期较恢复期明显增高(P<0.01);中度损伤组和重度损伤组患者血清IL-1β、TNF-α及sICAM-1水平均较轻度损伤组显著增高(P<0.01或P<0.05),重度损伤组患者TNF-α及sICAM-1水平较中度损伤组明显增高(P<0.01);多元线性回归分析结果显示,IL-1β、TNF-α及sICAM-1表达水平与脑梗死患者的神经功能缺损程度评分呈线性正相关,标准回归系数依次为0.618、0.613和0.606。结论:IL-1β、TNF-α及sICAM-1互相作用参与了急性脑梗死的炎症反应和再灌流损伤。对它们的监测可为早期临床治疗及康复干预提供试验指标,以便控制脑卒中的进展及复发。
Objective: To investigate the relationship between serum levels of inflammatory cytokines and severity of illness in patients with cerebral infarction. Methods: Totally 82 patients with cerebral infarction from January 2006 to December 2008 were selected as the research group and 80 healthy people from the outpatient clinic during the same period as the control group. The levels of tumor necrosis factor-α (TNF-α) and interleukin-1β IL-1β) and soluble intercellular adhesion molecule 1 (sICAM-1). Results: The levels of IL-1β, TNF-α and sI-CAM-1 in patients with acute cerebral infarction and convalescent cerebral infarction were significantly higher than those in control group (P <0.01 or P <0.05) (P <0.01). The serum levels of IL-1β, TNF-α and sICAM-1 in patients with moderate injury and severe injury were significantly higher than those in mild injury group (P <0.01 or P <0.05) The levels of TNF-α and sICAM-1 in patients with moderate to severe injury were significantly higher than those in moderate injury group (P <0.01). Multiple linear regression analysis showed that the expression of IL-1β, TNF-α and sICAM- There was a linear positive correlation between the scores and the standard regression coefficients of 0.618, 0.613 and 0.606. Conclusion: IL-1β, TNF-α and sICAM-1 are involved in the inflammatory reaction and reperfusion injury in acute cerebral infarction. Their monitoring can provide experimental indicators for early clinical treatment and rehabilitation interventions in order to control the progression and recurrence of stroke.