The Maritime Silk Road is not only a passageway for business and trade, but also the road of friendship betweeneast and west civilizations. The Indian Ocean tsunami in 2004 caused major damage to several coastal countries. Tsunami occurrence regularity and hazard analysis are needed to ensure economic and cultural exchange on the Maritime Silk Road. To explore and identify tsunami hazard on the Maritime Silk Road, the spatial and temporal characteristics of historical tsunami events were given out. Some useful information hidden in historical tsunamis was searched from source parameters, such as seismic magnitude, focal depth and water depth. The tsunami possibility in the case of earthquake occurrence was also studied, exploring the probability of tsunami caused by different magnitudes. The analysis result shows that tsunamis on the Maritime Silk Road mainly occurred in 8 major tectonic faults, each of which has different tsunami occurrence regularity. On the basis of statistical analysis, a numerical model was used to simulate the potential tsunamis and show the tsunami hazard levels along the coast of Maritime Silk Road. The research results of this paper can help the tsunami early wing and ensure the safety of economic and cultural exchanges on the Maritime Silk Road.