论文部分内容阅读
目的 探讨血管紧张素转换酶（ＡＣＥ） 基因多态性与多囊卵巢综合征的关系。方法 用聚合酶链反应（ＰＣＲ）对５６ 例多囊卵巢综合征（ＰＣＯＳ）患者、３０ 例正常妇女检测ＡＣＥ 基因插入或缺失（Ｄ／Ｉ） 的多态性，进行比较。结果 三种基因型所占比例，两组相比无显著性差异；ＰＣＯＳ组Ｄ等位基因频率（４２－０％ ）显著高于对照组（２６－６ ％ ）（ Ｐ＜ ０－０５） ；ＰＣＯＳ高雄激素血症组（Ｔ≥３－０ｎｍｏｌ／Ｌ）Ｄ等位基因频率显著高于非高雄激素血症组（ Ｔ＜ ３－０ｎｍｏｌ／Ｌ）（ Ｐ＜０－０１） 。结论 ＡＣＥ基因Ｄ等位基因的存在与肾素－ 血管紧张素系统（ＲＡＳ） 亢进所导致的ＰＣＯＳ高雄激素血症及不排卵有关，通过对ＡＣＥ基因的检测，了解ＰＣＯＳ患者有无ＲＡＳ功能亢进，可为临床上使用ＡＣＥ抑制剂来治疗该病提供依据，并且推测：通过ＡＣＥ基因的检测可能使ＰＣＯＳ所发展成的非胰岛素依赖性糖尿病（ＮＩＤＤＭ） 及心血管疾病得到早期预测和预防。
Objective To investigate the relationship between angiotensin converting enzyme (ACE) gene polymorphism and polycystic ovary syndrome. Methods Polymerase chain reaction (PCR) was used to detect the polymorphism of ACE gene insertion or deletion in 56 cases of PCOS and 30 normal women. Results There was no significant difference between the two genotypes in the three genotypes. The frequency of D allele in PCOS group was significantly higher than that in control group (42% -60%, P <0-05). The frequency of D allele in PCOS hyperandrogenism group (T≥3-0nmol / L) was significantly higher than that in non-hyperandrogenism group (T <3-0nmol / L) (P <0-01). Conclusions The existence of D allele of ACE gene is associated with hyperandrogenism and anovulation in PCOS caused by hyperthyroidism with renin - angiotensin system (RAS). The detection of ACE gene in PCOS patients is helpful for understanding the presence of RAS hyperactivity, It can provide a basis for the clinical use of ACE inhibitors to treat the disease and speculate that the detection of ACE gene may predict and prevent the development of non-insulin-dependent diabetes mellitus (NIDDM) and cardiovascular diseases.