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目的:分析不同治疗方法治疗先兆流产的疗效,总结治疗经验。方法:2015年1月~2017年1月,医院共处理早期先兆流产142例,进行超声、实验室检查诊断病因,黄体功能不足34例、血栓前状态54例、免疫因素26例(抗磷脂综合征11例,妊娠免疫不耐受15例)、其他因素28例,根据病因针对性的治疗,包括给予黄体酮、低分子肝素、免疫治疗以及中药治疗,加强孕期管理。结果:治疗后血HCG水平、D-二聚体水平、PLT、子宫螺旋动脉血流指数显著改善(P<0.05),抗磷脂抗体转阴4.5%(5/11)。保胎成功77.5%(110/142),保胎失败主要为复发性流产、不明原因先兆流产。结论:先兆流产的保胎失败率较高,针对病因治疗非常必要,对于复发性流产对象,有必要加强孕前的管理。
Objective: To analyze the curative effect of different treatment methods on threatened abortion, and to summarize the experience of treatment. Methods: From January 2015 to January 2017, 142 cases of early threatened abortion were treated in our hospital. Ultrasound and laboratory tests were performed to diagnose the etiology. There were 34 cases with corpus luteum insufficiency, 54 cases with prethrombotic state, 26 cases with immune factors (antiphospholipid syndrome Eleven patients were recruited, and 15 were immunologically intolerant to pregnancy). Other factors included 28 cases. According to the targeted therapy, progesterone, low molecular weight heparin, immunotherapy, and traditional Chinese medicine were given to strengthen pregnancy management. Results: After treatment, blood HCG level, D-dimer level, PLT, uterine spiral artery blood flow index were significantly improved (P <0.05), anti-phospholipid antibody negative 4.5% (5/11). Miscarriage success 77.5% (110/142), miscarriage failure mainly for recurrent miscarriage, unexplained threatened abortion. Conclusion: The rate of miscarriage failure in threatened abortion is high, so it is necessary to treat etiology. For recurrent miscarriage, it is necessary to strengthen pre-pregnancy management.