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自1975年以来,以血卟啉衍生物(Hema-toporphyrin derivative,HPD)为光敏剂的光敏疗法已用于某些癌症的治疗。Canti等在实验中曾发现 HPD 对小鼠免疫功能具有一定影响,而接受 HPD 的病人,当直接或间接暴露在阳光下时,也常出现皮肤光敏性变态反应。故本文拟观察国产 HPD 对正常小鼠免疫功能有何影响。
Photodynamic therapy with Hema-toporphyrin derivative (HPD) as a photosensitizer has been used for the treatment of certain cancers since 1975. In experiments, Canti et al. Found that HPD has some effect on immune function in mice, while patients receiving HPD often have photosensitive skin allergies when exposed directly or indirectly to sunlight. Therefore, this article intends to observe the impact of domestic HPD on immune function in normal mice.