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卵巢癌是一种具有遗传易感性的多因素疾病,患者的基因突变导致其对于卵巢癌易感性存在差异〔1〕。由于卵巢癌早期难以确诊,确诊时常属于晚期,研究患者具有特异性的分子标记物对于卵巢癌早期诊断,提高患者生存率与生活质量具有重要意义。DNA损伤作为表观遗传学的一部分,近年来成为了新的研究热点,包括DNA甲基化异常、过度磷酸化等,由于DNA损伤与抑癌基因密切相关,引起异常DNA被传递至子代细胞,是肿瘤抑制基因失活,进而产生肿瘤
Ovarian cancer is a multifactorial disease with genetic predisposition. Mutations in patients leading to their susceptibility to ovarian cancer differ [1]. Because early ovarian cancer is difficult to diagnose, diagnosed often belong to the late, the study of patients with specific molecular markers for the early diagnosis of ovarian cancer and improve patient survival and quality of life is of great significance. As a part of epigenetics, DNA damage has become a new research hotspot in recent years, including DNA methylation abnormality and hyperphosphorylation. Because DNA damage is closely related to tumor suppressor gene, abnormal DNA is transferred to daughter cells , Is a tumor suppressor gene inactivation, and then produce tumors