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Objective:To investigate the effect of Buyang Huanwu Decoction(补阳还五汤,BYHWD) on estradiol(E_2) and estradiol receptor(ER) in serum and brain in ovariectomized rats after middle cerebral artery occlusion(MCAO).Methods:Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO.Rats were randomly divided into normal,ovariectomy(OVX),MCAO,OVX+MCAO,OVX+MCAO+E_2,and OVX+MCAO+BYHWD group.Rats were administered BYHWD 5 g/kg daily,estradiol valerate 500 μg/kg per day or distilled water for 7 consecutive days.Neuronal function and infarct volume were measured on day 7 after artery occlusion,and E_2 and ER concentration in serum and brain were checked by enzyme-linked immunosorbent assay.Results:BYHWD significantly improved the neurological behavior,reduced the infarction volume,increased E_2concentration in serum and brain,and increased ER concentration in the brain in ovariectomized rats after MCAO.Conclusion:The neuroprotective effects of BYHWD are associated with estrogen and its receptor.
Objective: To investigate the effect of Buyang Huanwu Decoction (BYHWD) on estradiol (E2) and estradiol receptor (ER) in serum and brain in ovariectomized rats after middle cerebral artery occlusion (MCAO). Methods: Adult female rats were ovariectomized and focal cerebral ischemic was induced by MCAO.Rats were randomly divided into normal, ovariectomy (OVX), MCAO, OVX + MCAO, OVX + MCAO + E_2, and OVX + MCAO + BYHWD group. / kg daily, estradiol valerate 500 μg / kg per day or distilled water for 7 consecutive days. Neuronal function and infarct volume were measured on day 7 after artery occlusion, and E_2 and ER concentrations in serum and brain were checked by enzyme-linked immunosorbent assay. Results: BYHWD significantly improved the neurological behavior, reduced the infarction volume, increased E_2concentration in serum and brain, and increased ER concentration in the brain in ovariectomized rats after MCAO. Confc: The neuroprotective effects of BYHWD are associat ed with estrogen and its receptor.