抗生素后效应(PAE)是近年国外在抗菌药物领域受到关注的新理论,为抗生素对致病微生物的特有效应。PAE系指细菌接触抗生素一定时,当抗生素消除后,细菌生长仍能受到一段时间持续抑制的现象。目前发现,几乎所有抗生素都具有PAE。 1.同一抗生素对不同的细菌具有不同的PAE。 有人报道了环丙沙星对肺炎克雷白菌、绿脓杆菌临床分离菌株的PAE。环丙沙星在8MIC药物浓度下对肺炎克雷白菌的PAE为6.6±1.3h,绿脓杆菌的 The post-antibiotic effect (PAE) is a new theory that attracts much attention in the field of antibacterials abroad in recent years. It is a peculiar effect of antibiotics on pathogenic microorganisms. PAE refers to the bacteria in contact with antibiotics for a certain period, when the elimination of antibiotics, bacterial growth can still be sustained inhibition of the phenomenon for some time. It is now found that almost all antibiotics have PAE. 1. The same antibiotic has different PAEs to different bacteria. It was reported ciprofloxacin against Klebsiella pneumoniae, Pseudomonas aeruginosa clinical isolates of PAE. The PAE of Ciprofloxacin against Klebsiella pneumoniae at the concentration of 8MIC was 6.6 ± 1.3h, and that of Pseudomonas aeruginosa