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目的:观察干扰素治疗HCV-RNA<1000IU/ml反复转氨酶升高,应用保肝降酶药物难以持久控制的丙肝的疗效。方法:治疗组在保肝治疗基础上加用干扰素300万单位肌注隔日1次,对照组应用保肝降酶药物对症治疗,疗程1年。结果:治疗组转氨酶下降,肝纤维化指标,B超改变较对照组在统计学上有显著差异。结论:此类患者在知情同意的基础上可予抗病毒治疗。
Objective: To observe the interferon treatment of HCV-RNA <1000IU / ml repeatedly elevated transaminases, the application of liver protection and enzyme drugs is difficult to permanently control the efficacy of hepatitis C. Methods: The treatment group added 3 million units of interferon intramuscularly once every other day on the basis of hepatoprotective therapy, and the control group used the drugs of protecting liver and reducing enzymes for symptomatic treatment for 1 year. Results: The decrease of transaminase, the index of hepatic fibrosis and B-ultrasound in the treatment group were statistically significant difference compared with the control group. Conclusion: Such patients may be given antiviral treatment on the basis of informed consent.