Background:Malaria cases have declined significantly along the China-Myanmar border in the past 10 years and this region is going through a process from control to elimination.The aim of this study is to investigate the epidemiology of malaria along the border,will identify challenges in the progress from control to elimination.rnMethods:National reported malaria cases from China and Myanmar,along with the data of 18 Chinese border counties and 23 townships in Myanmar were obtained from a web-based diseases information reporting system in China and the national malaria control program of Myanmar,respectively.Epidemiological data was analyzed,includ-ing the number of reported cases,annual parasite index and proportion of vivax infection.Spatial mapping of the annual parasite index(API)at county or township level in 2014 and 2018 was performed by ArcGIS.The relationship of malaria endemicity on both sides of the border was evaluated by regression analysis.rnResults:The number of reported malaria cases and API declined in the border counties or townships.In 2014,392 malaria cases were reported from 18 Chinese border counties,including 8.4％indigenous cases and 91.6％imported cases,while the highest API(0.11)was occurred in Yingjiang County.There have been no indigenous cases reported since 2017,but 164 imported cases were reported in 2018 and 97.6％were imported from Myanmar.The average API in 2014 in 23 Myanmar townships was significantly greater than that of 18 Chinese counties(P＜0.01).However,the API decreased significantly in Myanmar side from 2014 to 2018(P＜ 0.01).The number of townships with an API between 0 and 1 increased to 15 in 2018,compared to only five in 2014,while still four townships had API ＞10.Plas-modium vivax was the predominant species along the border.The number of reported malaria cases and the propor-tion of vivax infection in the 18 Chinese counties were strongly correlated with those of the 23 Myanmar townships(P＜0.05).rnConclusions:Malaria elimination is approaching along the China-Myanmar border.However,in order to achieve the malaria elimination in this region and prevent the re-establishment of malaria in China after elimination,continued political,financial and scientific commitment is required.