论文部分内容阅读
目的 探讨长期使用苯二氮革类药物(benzodiazepines,BZDs)对老年社区获得性肺炎(community-acquired pneumonia,CAP)发展和预后的影响.方法 回顾性调查患者临床信息,根据是否长期使用BZDs分成观察组(84例)和对照组(103例),两组间一般资料比较,差异无统计学意义(P＞0.05).两组患者均进行常规的CAP治疗,比较两组患者的治疗效果、肺炎进展和预后情况.结果 两组治疗疗效比较,差异有统计学意义(P＜0.05);观察组临床肺部感染评分(CPIS)于治疗后7天起明显低于治疗前(P＜0.05),晚于对照组;观察组病死率、转入危重监护病房(intensive care unit,ICU)比例、住院费用和天数均高于对照组,差异有统计学意义(P＜0.05),不良反应比较,差异无统计学意义(P＞0.05).结论 长期使用BZDs的老年CAP患者抗感染效果劣于未使用者,且预后不佳,在老年CAP的治疗中,需慎用BZDs.“,”Objective To study the influence of long-term use of BZDs on the process and prognosis of elderly CAP.Methods The clinical information of the patients was retrospectively analyzed.According to whether the long-term use of BZDs was divided into the observation group (84 cases) and the control group (103 cases),there was no significant difference between the two groups (P ＞ 0.05).Two groups of patients were treated with conventional CAP,compared the two groups of patients with treatment,progress and prognosis of pneumonia.Results There was significant difference (P ＜ 0.05) in the therapeutic effect between the two groups;CPIS of the observation group after the treatment of 7d was significantly lower than that before treatment (P ＜ 0.05),later than that of the control group.The mortality rate,ICU ratio,hospitalization cost and days of the observation group were significantly higher than those of the control group (P ＜ 0.05).Adverse reactions were no significant difference (P ＞ 0.05) between the two groups.Conclusion Long-term using BZDs is not beneficial to the elderly CAP patients and worsen the prognosis situation.Therefore the clinical application of BZDs to elderly CAP patients should be made with cautiousness.