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目的:通过分析女性绝经期不同骨密度人群的血浆同型半胱氨酸(HCY)指标,探讨同型半胱氨酸在女性绝经期骨质疏松发生过程中的作用及其潜在的临床价值。方法:收集2014年3月至2016年3月我院体检中心进行体检的女性绝经期妇女(>60岁)血样标本共计625例,根据体检的骨密度报告对其进行分组,骨质疏松组215例,骨量减少组309例,骨量正常组101例,测量每组的同型半胱氨酸水平。结果:骨密度程度与同型半胱氨酸水平存在负相关关系(rs=-0.763,P=0.046),三组之间的同型半胱氨酸水平也存在显著差异(F=4.807,P<0.016),其中骨质疏松组指标最高,骨量正常组指标最低。结论:同型半胱氨酸是重要的骨代谢指标,在衡量绝经期妇女骨质疏松进展中具有重要的意义。
OBJECTIVE: To investigate the role of homocysteine in the development of female osteoporosis during menopause and its potential clinical value by analyzing the plasma homocysteine (HCY) in women with different bone mineral density at menopause. Methods: A total of 625 blood samples were collected from female postmenopausal women (> 60 years old) for physical examination from March 2014 to March 2016 in our hospital’s physical examination center. The blood samples were collected according to the physical examination’s BMD. The osteoporosis group 215 Cases, 309 cases of osteopenia group, 101 cases of normal bone mass group, measuring homocysteine levels in each group. Results: There was a negative correlation between the degree of bone mineral density (BMD) and homocysteine level (rs = -0.763, P = 0.046). There was also a significant difference in homocysteine levels between the three groups (F = 4.807, P <0.016 ), Of which osteoporosis group had the highest index and the group with normal bone mass had the lowest index. Conclusion: Homocysteine is an important indicator of bone metabolism and plays an important role in measuring the progress of osteoporosis in postmenopausal women.