通常认为各种病因引起肝脏损伤和炎症反应后,在其修复的过程中由于细胞外基质(ECM)异常增多和过度沉积而未形成假小叶时,称之为肝纤维化。它是各种慢性肝病向肝硬化发展的主要中间环节。肝纤维化的形成机制非常复杂,包括有众多因素的参与。目前肝星状细胞(HSC)被认为是ECM的主 It is generally considered that various etiologies cause hepatic injury and inflammation and are referred to as hepatic fibrosis when pseudolobules are not formed during the repair process due to an abnormal increase and excessive deposition of extracellular matrix (ECM). It is a variety of chronic liver disease to the development of cirrhosis of the main intermediate links. The mechanism of formation of liver fibrosis is very complex and involves many factors. Current hepatic stellate cells (HSC) is considered the main ECM