氢氯噻嗪是常用的高血压降压药物,疗效受到患者药物基因组学特征影响.现综述近年来的相关研究进展,蛋白激酶C-α基因的rs16960228、神经前体细胞表达的发育性下调4样蛋白基因的rs4149601、含有4的YEATS域基因的rs7297610、G-蛋白a亚单位-内皮素-3基因的rs2273359、缝隙连接蛋白α1基因的rs10499113和rs2104334,以及叉头样A1基因的rs177852的基因多态性可能影响氢氯噻嗪的降压效果,并阐述其表达蛋白的功能学研究.“,”Hydrochlorothiazide is a commonly used hypertension antihypertensive drug,however,its efficiency is affected by patient pharmacogenomics characteristics.This paper reported the research advances in pharmacogenomics studies of hydrochlorothiazide.It was reported that blood pressure lowering responses were different when patients presented polymorphisms of the following;rs16960228 in protein kinase C-alpha gene,expression in neural precursor cell rs 4149601,developmental down-regulated 4-like gene,rs7297610 in YEATS domain containing 4 gene,rs2273359 in G-protein alpha subunit-endothelian-3 gene,rs10499113 and rs2104334 in gap junction protein α1 gene,or rs177852 in fork-head box A1 gene.In this paper,the functions of encoding proteins were discussed to reveal the potential antihypertensive mechanisms.